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Synthesis 2010(7): 1150-1158  
DOI: 10.1055/s-0029-1218654
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Bifunctional Hydroxamic Acids as Novel Ligands for the Hydrophilic Stabilization of Iron Oxide Nanoparticles

Andreas Hofmann*a, Christina Graf*a, Shih-Hao Kunga, Myeongseob Kimb, Xiaogang Pengb, Randa El-Aamaa, Eckart Rühla
a Physikalische Chemie, Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
Fax: +49(30)83852717; e-Mail: ah79@chemie.fu-berlin.de; e-Mail: cmgraf@chemie.fu-berlin.de;
b Department of Chemistry and Biochemistry, University of Arkansas, Dickson Street, Fayetteville, AR 72701, USA
Further Information

Publication History

Received 12 August 2009
Publication Date:
29 January 2010 (online)

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Abstract

A general method for synthesizing bifunctional hydroxamic acids containing carboxylic acid or amino functionalities is reported. Various products from simple alkyl to complex dendrimer-like structures are described. Such molecules have recently been used in ligand-exchange reactions for the hydrophilic stabilization of originally oleic acid protected iron oxide nanoparticles.

Key words

protecting groups - hydroxamic acids - hydrogenation - ethers - alkylations

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Hofmann, A.; Graf, C.; Semisch, A.; Hartwig, A.; Rühl, E. manuscript in preparation.