A Synthesis of the C₃-C₁₅ Fragment of the Archazolids

Abstract

Ring-closing metathesis and an allylation-elimination reaction sequence have been used to complete a synthesis of the conjugated triene subunit of the archazolids.

Key words

stereoselective synthesis - tandem reactions - allylations - eliminations - metathesis

References and Notes

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14

The stereochemistry was later confirmed by NMR analysis. See Supporting Information for details.

16

A similar conjugated triene product was obtained with comparable yield and selectivity from an acyclic substrate (Scheme 6); see Supporting Information for details.

Scheme 6