Suzuki-Miyaura Coupling with Sn₆O₆-Pd Nanocomposites

Significance

A palladium nanocomposite, NP-1, was prepared by the reduction of PdCl₂ with NaBH₄ in the presence of a phosphine-rich hexa-meric organostannoxanne, PDrum, in 90% yield. Treatment of NP-1 with hexane gave another palladium nanocomposite, NP-2, in 65% yield. The NP-1-catalyzed Suzuki-Miyaura reaction of aryl halides 1a-i, including the aryl chlorides, with phenylboronic acid (2) in refluxing toluene gave the corresponding biaryls 3a-i in 67-99% yield. NP-2 promoted the cross-coupling in refluxing methanol to afford the corresponding biaryls 3a-h in 40-99% yield.