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Synfacts 2009(11): 1258-1258  
DOI: 10.1055/s-0029-1218039
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Direct Arylation of Polyfluoroarenes with Arylboronic Acids

Contributor(s): Paul Knochel, Tobias Thaler
Y. Wei, J. Kan, M. Wang, W. Su*, M. Hong
Fujian Institute of Research on the Structure of Matter, P. R. of China
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Publikationsdatum:
22. Oktober 2009 (online)

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Significance

An efficient method for the Pd-catalyzed arylation of polyfluoroarenes using boronic acids has been developed. Polyfluoroarenes with various substitution patterns and functionalizations could be selectively arylated. The choice of an appropriate base with respect to the acidities of the polyfluorobenzenes used is hereby crucial for achieving a broad substrate scope.