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Synfacts 2009(10): 1117-1117  
DOI: 10.1055/s-0029-1217918
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Asymmetric Cyclopropanation

Contributor(s): Hisashi Yamamoto, Zhi Li
W. Liu, D. Chen, X.-Z. Zhu, X.-L. Wan, X.-L. Hou*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Highly diastereo- and enantioselective cyclopropanation is achieved with Pd-Sioc­Phox (L1-3) catalysts, allyl carbonates and acyclic amides. In this reaction, the amides act as nucleophiles to attack the central carbon of the π-allyl-Pd intermediate generated from Pd species and allyl carbonates. The authors examined the reaction conditions, additives as well as substrate scope.