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Synfacts 2009(10): 1082-1082  
DOI: 10.1055/s-0029-1217910
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Indolo [1,2,5]-Triazepines and [1,2,5]-Oxadiazines

Contributor(s): Victor Snieckus, Johnathan Board
G. Reddy, P. A. Kumar, R. V. Anand, K. Mukkanti, P. P. Reddy*
Dr. Reddy’s Laboratories Ltd., Bachupally and Jawaharlal Nehru Technological University, Hyderabad, India
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Publikationsverlauf

Publikationsdatum:
22. September 2009 (online)

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Significance

Reported is the synthesis of two types of indoloazepines from simple condensation of the 1H-indole-2-carbonitrile common intermediate with aromatic-acyl bromides. The N-substituted intermediate derivate is then subjected to reaction with either hydrazine hydrate (as solvent as well as reagent) to give the [1,2,5]-triazepines or with hydroxylamine hydrochloride to give the [1,2,5]-oxadiazine derivatives.