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Synfacts 2009(10): 1111-1111  
DOI: 10.1055/s-0029-1217851
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-Catalyzed Decarboxylative Asymmetric Mannich-Type Reaction

Contributor(s): Mark Lautens, Jacki Kitching
L. Yin, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
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Publikationsdatum:
22. September 2009 (online)

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Significance

The synthesis of β²,²,³-amino acid precursors via a copper-catalyzed decarboxylative Mannich-type reaction is described. Hydro­lysis of these precursors under acidic conditions then allows for the preparation of enantiomerically enriched amino acid derivatives.