Pd-Catalyzed Asymmetric α-Arylation and α-Vinylation of Oxindoles

Significance

The authors have developed the Pd-catalyzed enantioselective α-arylation and α-vinylation of oxindoles using a ligand with both axial and phosphorus-based chirality. The products having all-carbon quaternary centers were obtained with excellent enantioselectivities and in good yields. Moreover, the α-aryl and α-vinyl oxindole products were further derivatized without any loss of optical activity.