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Synlett 2009(15): 2487-2491  
DOI: 10.1055/s-0029-1217745
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Tetramic Acids as Scaffolds: Synthesis, Tautomeric and Antibacterial Behaviour

Yong-Chul Jeong, Mark G. Moloney*
Chemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK
Fax: +44(1865)275002; e-Mail: mark.moloney@chem.ox.ac.uk;
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Publication History

Received 26 May 2009
Publication Date:
27 August 2009 (online)

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Abstract

Efficient synthetic routes for tetramic acids variously substituted on the ring nitrogen, their tautomeric behaviour in solution and their antibiotic activity are reported.

Key words

heterocycles - tautomerism - natural products - drugs

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