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Synthesis 2010(3): 527-537  
DOI: 10.1055/s-0029-1217145
FEATUREARTICLE
© Georg Thieme Verlag Stuttgart ˙ New York

Total Synthesis of Halicholactone and Neohalicholactone

Martina Bischop, Verena Doum, Anja C. M. Nordschild née Rieche, Jörg Pietruszka*, Diana Sandkuhl
Institut für Bioorganische Chemie der Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Stetternicher Forst Geb. 15.8, 52426 Jülich, Germany
Fax: +49(2461)616196; e-Mail: j.pietruszka@fz-juelich.de;
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Publication History

Received 16 October 2009
Publication Date:
27 November 2009 (online)

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Abstract

New total syntheses of the marine oxylipins halicholactone and neohalicholactone are presented. The key building blocks were synthesized utilizing chemoenzymatic methods.

Key words

natural product - total synthesis - enzymes - boron reagents - asymmetric synthesis

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17

All enzymes are commercially available from Codexis Inc. and were used as purchased.