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Synthesis 2010(3): 486-492  
DOI: 10.1055/s-0029-1217143
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Tandem Synthesis of Furo[3,2-h]quinolines by a Sonogashira Cross-Coupling and Cyclization Reaction Supported by Basic Alumina Under Microwave Irradiation

Pritam Saha, Subhendu Naskar, Rupankar Paira, Shyamal Mondal, Arindam Maity, Krishnendu B. Sahu, Priyankar Paira, Abhijit Hazra, Diptendu Bhattacharya, Sukdeb Banerjee, Nirup B. Mondal*
Department of Chemistry, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032, India
Fax: +91(33)24735197; e-Mail: nirup@iicb.res.in;
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Publikationsverlauf

Received 24 September 2009
Publikationsdatum:
24. November 2009 (online)

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Abstract

Acetylenic 8-quinolinols generated in situ by the Sonogashira cross-coupling reaction are efficiently converted into furo[3,2-h]quinolines by microwave-assisted, copper-catalyzed, intramolecular cyclization in the presence of basic alumina.

Key words

heterocycles - furoquinoline - cross-coupling - cyclizations - solid-phase synthesis - microwave irradiation

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