A Practical Synthesis of 1-N-SEM-Protected 3-Iodo-7-methyl-2-piperidin-3-ylindole

Abstract

A convenient procedure for the preparation of the 1-N-SEM-protected 3-iodo-7-methyl-2-piperidin-3-ylindole 3 is described. This scaffold provides access to unique and diverse 7-methyl-substituted indole libraries.

Key words

7-methylindoles - Fischer cyclization - 3-iodoindoles - 1,2,3,7-substituted indoles

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