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Synthesis 2010(1): 30-32  
DOI: 10.1055/s-0029-1217055
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Concise Regiospecific Synthesis of 5-Chloropyrido[4,3-d]pyrimidin-4(3H)-one

Yahua Liu, Qiang Ding, Xu Wu*
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
Fax: +1(858)8121942; e-Mail: xwu@gnf.org;
Further Information

Publication History

Received 15 July 2009
Publication Date:
19 October 2009 (online)

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Abstract

A concise synthesis of 5-chloropyrido[4,3-d]pyrimidin-4(3H)-one was developed based on a unique regiospecific introduction of a tert-butoxycarbonyl group at the C-3 position of 4-amino-2-chloropyridine.

Key words

pyridopyrimidines - pyridines - rearrangement - regio­specificity - medicinal chemistry

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