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Synthesis 2009(21): 3593-3602  
DOI: 10.1055/s-0029-1216984
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium(0)-Catalyzed Intramolecular Heck Reaction: A Resourceful Route for the Synthesis of Naphthoxepine and Naphthoxocine Derivatives

K. C. Majumdar*, Inul Ansary, Biswajit Sinha, Buddhadeb Chattopadhyay
Department of Chemistry, University of Kalyani, Kalyani 741235, India
e-Mail: kcm_ku@yahoo.co.in;
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Publication History

Received 25 May 2009
Publication Date:
28 August 2009 (online)

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Abstract

The synthesis of oxocines and oxepines is difficult. Two efficient protocols have been developed for the construction of naphthoxepine and naphthoxocine derivatives by sequential Wittig olefination and intramolecular Heck reaction.

Key words

Wittig olefination - oxepines - oxocines - Heck cyclization - palladium catalysis

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