A Novel Diastereoselective Synthesis of β-Phosphonato Unsaturated Thioimidates

Abstract

A novel, convenient, and efficient approach to the synthesis of α,β-unsaturated thioimidates with a phosphonate functional group in β-position has been reported based on a multicomponent reaction. The generated zwitterions from the reaction of trialkyl phosphites and dialkyl acetylenedicarboxylates are trapped with benzenecarbonyl isothiocyanate to produce the title compounds in good yield.

Key words

thioimidate - trialkyl phosphite - dialkyl acetylenedicarboxylate - benzenecarbonyl isothiocyanate - multicomponent reaction

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