Efficient Synthesis of 2-Substituted Pyrido[3,2-d]pyrimidines Involving S_NAr and Palladium-Catalyzed Cross-Coupling Reactions

Abstract

The efficient and original synthesis of various 2-substituted pyrido[3,2-d]pyrimidines is reported. Starting from 2,4-dichloropyrido[3,2-d]pyrimidine, a regioselective pallado-dehalogenation led to 2-chloropyrido[3,2-d]pyrimidine, which was used in S_NAr and palladium-catalyzed cross-coupling reactions in order to afford highly functionalized products in very good yields.

arylations - amination - palladium

References

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