Various aromatic and aliphatic aldehydes were converted into
the corresponding 2-aryl and 2-alkyl-2-oxazolines, respectively,
in good to high yields by reaction with 2-aminoethanol and 1,3-diiodo-5,5-dimethylhydantoin.
Moreover, chiral bis-2-oxazolines, which can be used as chiral ligands
in asymmetric synthesis, could be also prepared in moderate yields
by the reaction of dialdehydes with (R)-(-)-2-phenylglycinol
under the same conditions.
2-aryl-2-oxazoline - 2-alkyl-2-oxazoline - 1,3-diiodo-5,5-dimethylhydantoin - aldehyde
- 2-aminoethanol - chiral oxazoline