Planta Med 2009; 75(4): 340-345
DOI: 10.1055/s-0028-1112212
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Phenylpropanoid and Lignan Derivatives from Antiaris toxicaria and their Effects on Proliferation and Differentiation of an Osteoblast-Like Cell Line

Miao-Miao Jiang1 , Hao Gao2 , Yi Dai2 , Xue Zhang3 , Nai-Li Wang3 , Xin-sheng Yao2 , 3
  • 1Central Laboratory of Guangdong Pharmaceutical University, Guangzhou, P. R. China
  • 2Institutes of Traditional Chinese Medicine and Natural Product, Jinan University, Guangzhou, P. R. China
  • 3College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, P. R. China
Further Information

Publication History

Received: January 25, 2008 Revised: October 28, 2008

Accepted: November 4, 2008

Publication Date:
30 January 2009 (online)

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Abstract

Antiarisin A and B (1 and 2), together with seventeen known compounds (3 – 19), were isolated from the EtOAc extract of the stem of Antiaris toxicaria Lesch. Their structures were determined on the basis of spectroscopic analyses and chemical methods. Most of the compounds were reported for the first time from the Antiaris genus and firstly studied for their proliferative and differentiative activity on osteoblast-like cells. Screening results indicated that, at the concentration of 10 – 8 M, benzofuran lignans 5, 6, 11 and 13 could significantly stimulate the proliferation of UMR106 cells, while 8, 9, 11, 14, 15 and 17 could enhance ALP (alkaline phosphatase) activity.

References

Prof. Xin-Sheng Yao

Institute of Traditional Chinese Medicine & Natural Products

Jinan University

Guangzhou 510632

People's Republic of China

Phone: +86-20-8522-5849

Fax: +86-20-8522-1559

Email: yaoxinsheng@vip.tom.com

Dr. Xue Zhang

College of Traditional Chinese Medicine

Shenyang Pharmaceutical University

Shenyang 110016

People's Republic of China

Email: zxalice@sohu.com