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Synthesis 2008(21): 3461-3464
DOI: 10.1055/s-0028-1093170
DOI: 10.1055/s-0028-1093170
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkMagnesium-Cadmium Chloride, a Bimetallic Catalyst System for the Allylation of Aldehydes with Allyl Bromide: An Efficient Protocol for the Synthesis of Homoallylic Alcohols
Further Information
Received
23 June 2008
Publication Date:
16 October 2008 (online)
Publication History
Publication Date:
16 October 2008 (online)

Abstract
A simple and efficient procedure for the allylation of aldehydes has been developed using the magnesium-cadmium chloride reagent system. This bimetallic catalytic system works well in a tetrahydrofuran-water solvent medium. A variety of aldehydes undergo smooth nucleophilic addition with allyl bromide to afford the corresponding homoallylic alcohols in excellent yields. All the reactions were performed at room temperature.
Key words
aldehydes - homoallylic alcohols - bimetallic catalyst - allyl bromide
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