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Synthesis 2009(9): 1459-1462
DOI: 10.1055/s-0028-1088161
DOI: 10.1055/s-0028-1088161
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkNovel and Efficient Methods for the Synthesis of Symmetrical Trisulfides
Further Information
Received
5 November 2008
Publication Date:
25 March 2009 (online)
Publication History
Publication Date:
25 March 2009 (online)
Abstract
We have developed convenient methods for the synthesis of symmetrical trisulfides under mild conditions in very good yields. The described methods are based on the straightforward preparation of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorin-2-yl)disulfanyl derivatives from readily available 5,5-dimethyl-2-sulfanyl-2-thioxo-1,3,2-dioxaphosphorinane or bis(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl) disulfide. The symmetrical trisulfides can be obtained from aliphatic and aromatic thiols and also l-cysteine derivatives.
Key words
symmetrical trisulfides - thiols - sulfenyl bromides - l-cysteine
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