A Robust Synthesis of Nε-(Carboxymethyl)-l-lysine (CML)

René Csuk; Sebastian Stark; Alexander Barthel; Ralph Kluge; Dieter Ströhl

doi:10.1055/s-0028-1088064

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A Robust Synthesis of N ^ε-(Carboxymethyl)-l-lysine (CML)

René Csuk*, Sebastian Stark, Alexander Barthel, Ralph Kluge, Dieter Ströhl
Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Straße 2, 06120 Halle, Germany
Fax: +49(345)5527030; e-Mail: rene.csuk@chemie.uni-halle.de;

Abstract

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Abstract

N ^ε-(Carboxymethyl)-l-lysine is easily obtained by reductive amination of glyoxylic acid with N ^α-acetyl-l-lysine in the presence of a palladium catalyst and hydrogen.

Key words

amino acids - medicinal chemistry - hydrogenation - aminations - reductions

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References

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A Robust Synthesis of N ε-(Carboxymethyl)-l-lysine (CML)

A Robust Synthesis of N ^ε-(Carboxymethyl)-l-lysine (CML)