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Synlett 2008(20): 3239-3241  
DOI: 10.1055/s-0028-1087368
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Propylene Oxide Assisted Sonogashira Coupling Reaction

Zhaolong Tonga, Peng Gaoa,b, Haibing Denga, Lei Zhanga, Peng-Fei Xub, Hongbin Zhai*a,b
a Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China
b State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, P. R. of China
Fax: +86(21)64166128; e-Mail: zhaih@mail.sioc.ac.cn;
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Publication History

Received 5 June 2008
Publication Date:
26 November 2008 (online)

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Abstract

A propylene oxide assisted base-free Sonogashira cross-coupling reaction has been developed. The unique feature of the current protocol has extended the scope of Sonogashira reaction to some base-sensitive substrates.

Key words

base-free - propylene oxide - Sonogashira reaction

    References and Notes

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