Palladium-Catalyzed Asymmetric α-Arylation of Aldehydes

Significance

The authors report the first asymmetric version of the α-arylation of aldehydes under palladium catalysis. The examples illustrated are all intramolecular, generating five- and six-membered rings. The method forms all-carbon- substituted quaternary centers in high enantioselectivity and moderate yield.