Novel P-O-P Ligands for Highly Efficient Hydrogenation of
Alkenes

doi:10.1055/s-0028-1083621

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Synfacts 2008(12): 1310-1310
DOI: 10.1055/s-0028-1083621

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Novel P-O-P Ligands for Highly Efficient Hydrogenation of Alkenes

Contributor(s): Hisashi Yamamoto, Marina Naodovic
H. Fernández-Pérez, M. A. Pericàs, A. Vidal-Ferran*
Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Universitat de Barcelona and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

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Publikationsverlauf

Publikationsdatum:
20. November 2008 (online)

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Significance

In this account, the preparation and application of a library of novel P-O-P ligands for asymmetric hydrogenation is described. Various phosphine-phosphinite and phosphine-phosphite ligands were easily prepared from enantiopure Sharpless epoxy ethers. While several provide moderate levels of enantioselectivity and/or reactivity, ligand 1 was found to be highly efficient for the hydrogenation of different alkenes.