Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2008(12): 1288-1288
DOI: 10.1055/s-0028-1083613
DOI: 10.1055/s-0028-1083613
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Amino Acid Derived Sulfinamide Ligands for Transfer Hydrogenation
L. Zani, L. Eriksson, H. Adolfsson*
Stockholm University, Sweden
Further Information
Publication History
Publication Date:
20 November 2008 (online)

Significance
While chiral sulfoxides have found numerous applications as chiral ligands in various asymmetric transformations, few reports of related chiral sulfinamides as ligands exist. Here, the authors describe the design and synthesis of several chiral sulfinamides from simple amino acids. With ruthenium as metal source, these ligands were applied in the asymmetric transfer hydrogenation of several acetophenone derivatives to give products in modest yields and with high ee values.