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Synfacts 2008(12): 1320-1320  
DOI: 10.1055/s-0028-1083592
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Carboxylic Acid Derivatives through Carbonylation of Aryl Chlorides

Contributor(s): Paul Knochel, Andreas J. Wagner
D. A. Watson, X. Fan, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

A mild, functional group tolerant method for the preparation of arylcarboxylic acids, esters, amides and thiol esters from the corresponding aryl chlorides in the presence of CO is described. The reaction has a broad scope and generally proceeds in high yields.