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Synthesis 2008(24): 3937-3940  
DOI: 10.1055/s-0028-1083247
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Chemoselective, Easy Bromination of (Hydroxymethyl)phenols

Giammario Nieddu, Lidia De Luca*, Giampaolo Giacomelli
Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, 07100 Sassari, Italy
Fax: +30(079)212069; e-Mail: ldeluca@uniss.it;
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Publication History

Received 23 July 2008
Publication Date:
01 December 2008 (online)

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Abstract

A simple and chemoselective method for direct bromination of (hydroxymethyl)phenols via reaction with 2,4,6-trichloro[1,3,5]triazine in N,N-dimethylformamide at room temperature is described. The reaction occurs without affecting the phenolic hydroxy group.

Key words

(hydroxymethyl)phenols - cyanuric acid - (bromomethyl)phenols - bromination - chemoselectivity

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