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Synthesis 2008(24): 4007-4011  
DOI: 10.1055/s-0028-1083239
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Multicomponent Reactions as a Powerful Tool for Generic Drug Synthesis

Cédric Kalinski*, Hugues Lemoine, Jürgen Schmidt, Christoph Burdack, Jürgen Kolb, Michael Umkehrer, Günther Ross
Priaxon AG, Gmunder Str. 37-37a, 81739 München, Germany
Fax: +49(89)452130822; e-Mail: kalinski@priaxon.com;
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Publication History

Received 11 April 2008
Publication Date:
01 December 2008 (online)

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Abstract

Multicomponent reactions (MCRs) are not only a powerful tool for drug discovery, they also represent an excellent methodology for synthesis rationalization. Here we wish to illustrate the potential of MCRs in the production of generic drugs by synthesizing, in racemic form, the antiplatelet agent clopidogrel and the non-steroidal antiandrogen bicalutamide, using Ugi, Petasis and Passerini reactions.

Key words

multicomponent reactions - drugs - cleavage - clopido­grel - bicalutamide

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