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Synthesis 2008(21): 3423-3428  
DOI: 10.1055/s-0028-1083177
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Multicomponent Domino Cyclization-Oxidative Aromatization on a Bifunctional Pd/C/K-10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines

Omar De Paolis, Jonathan Baffoe, Shainaz M. Landge, Béla Török*
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd. Boston, MA 02125, USA
Fax: +1(617)2876030; e-Mail: bela.torok@umb.edu;
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Publication History

Received 23 May 2008
Publication Date:
16 October 2008 (online)

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Abstract

A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization (dehydrogenation) approach is described. The process is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediates to the desired products.

Key words

Pd/C/K-10 montmorillonite - solid acid - microwave irradiation - bifunctional catalysis - green chemistry - pyridines

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