Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000084.xml
Download PDF
Synthesis
DOI: 10.1055/a-2744-6345
DOI: 10.1055/a-2744-6345
Short Review
Published as part of the Special Issue in Honor of Prof. Michelle Chang, the 2023
Women in Chemistry Award Winner
Biosynthesis and Synthesis of Griseoviridin and Viridogrisein
Authors
Supported by: National Institute of General Medical Sciences R35 GM128895
Abstract
Griseoviridin and viridogrisein are synergistic type A/B streptogramin antibiotics that cooperatively inhibit protein translation in Gram-positive pathogens. This review provides an overview of their discovery and bioactivity and highlights key biosynthetic and synthetic advances that have enabled analog development to address antibiotic resistance. The review is organized into five sections.
Publication History
Received: 04 September 2025
Accepted after revision: 11 November 2025
Accepted Manuscript online:
11 November 2025
Article published online:
04 December 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
-
References
- 1 Bartz QR. Antibiotics Ann 1955; 1954: 777
- 2 Bartz QR, John E, Penner KM, Smith RM. Google Patents US3023204A 1962
- 3 Reissier S, Cattoir V. Expert Rev Anti-Infect Ther 2021; 19: 587
- 4 Mukhtar TA, Wright GD. Chem Rev 2005; 105: 529
- 5 Johnston N, Mukhtar T, Wright G. CDT 2002; 3: 335
- 6 Pechère J-C. Drugs 1996; 51: 13
- 7 Birnbaum GI, Hall SR. J Am Chem Soc 1926; 1976: 98
- 8 Dvorak CA, Schmitz WD, Poon DJ. et al. Angew Chem Int Ed 2000; 39: 1664
- 9 Sheehan JC, Zachau HG, Lawson WB. J Am Chem Soc 1958; 80: 3349
- 10 Neu HC, Chin N-X, Gu J-W. J Antimicrob Chemother 1992; 30: 83
- 11 Cocito C. Microbiol Rev 1979; 43: 145
- 12 Bouanchaud DH. J Antimicrob Chemother 1992; 30: 95
- 13 Mast Y, Wohlleben W. Int J Med Microbiol 2014; 304: 44
- 14 Haste NM, Perera VR, Maloney KN. et al. J Antibiot 2010; 63: 219
- 15 Hosoda K, Koyama N, Kanamoto A, Tomoda H. Molecules 2019; 24: 1495
- 16 Cocito C, Di Giambattista M, Nyssen E, Vannuffel P. J Antimicrob Chemother 1997; 39: 7
- 17 Chinali G, Moureau P, Cocito CG. J Biol Chem 1984; 259: 9563
- 18 Chinali G, Nyssen E, Di Giambattista M, Cocito C. Biochim Biophys Acta, Gene Struct Express 1988; 949: 71
- 19 Di Giambattista M, Ide G, Engelborghs Y, Cocito C. J Biol Chem 1984; 259: 6334
- 20 Moureau P, Engelborghs Y, Di Giambattista M, Cocito C. J Biol Chem 1983; 258: 14233
- 21 Moureau P, Di Giambattista M, Cocito C. Biochim Biophys Acta, Gene Struct Express 1983; 739: 164
- 22 Nyssen E, Di Giambattista M, Cocito C. Biochim Biophys Acta, Gene Struct Express 1989; 1009: 39
- 23 Leclercq R, Courvalin P. Antimicrob Agents Chemother 1991; 35: 1267
- 24 Weisblum B. Antimicrob Agents Chemother 1995; 39: 577
- 25 Allignet J, Loncle V, El Solh N. Gene 1992; 117: 45
- 26 Korczynska M, Mukhtar TA, Wright GD, Berghuis AM. Proc Natl Acad Sci USA 2007; 104: 10388
- 27 Roberts MC. MB 2002; 20: 261
- 28 Hershberger E, Donabedian S, Konstantinou K, Zervos MJ, Eliopoulos GM. Clin Infect Dis 2004; 38: 92
- 29 Poehlsgaard J, Douthwaite S. Nat Rev Microbiol 2005; 3: 870
- 30 Nishino K, Yamasaki S, Nakashima R, Zwama M, Hayashi-Nishino M. Front Microbiol 2021; 12
- 31 Schindler BD, Kaatz GW. Drug Resist Updat 2016; 27: 1
- 32 Wendlandt S, Lozano C, Kadlec K. et al. J Antimicrob Chemother 2013; 68: 473
- 33 Novotna G, Janata J. Antimicrob Agents Chemother 2006; 50: 4070
- 34 Reynolds E, Ross JI, Cove JH. Int J Antimicrob Agents 2003; 22: 228
- 35 Schwendener S, Donà V, Perreten V. Antimicrob Agents Chemother 2020; 64
- 36 Sugantino M, Roderick SL. Biochemistry 2002; 41: 2209
- 37 Stogios PJ, Kuhn ML, Evdokimova E, Courvalin P, Anderson WF, Savchenko A. Antimicrob Agents Chemother 2014; 58: 7083
- 38 Li Q, Pellegrino J, Lee DJ. et al. Nature 2020; 586: 145
- 39 Mukhtar TA, Koteva KP, Wright GD. Chem Biol 2005; 12: 229
- 40 Handzlik J, Matys A, Kieć-Kononowicz K. Antibiotics 2013; 2: 28
- 41 Shariati A, Dadashi M, Chegini Z. et al. Antimicrob Resist Infect Control 2020; 9: 56
- 42 Xie Y, Wang B, Liu J. et al. ChemBioChem 2012; 13: 2745
- 43 Xie Y, Li Q, Song Y, Ma J, Ju J. ChemBioChem 2014; 15: 1183
- 44 Li Q, Chen Y, Zhang G, Zhang H. FEBS Lett 2017; 591: 1295
- 45 Stout CN, Renata H. J Am Chem Soc 2024; 146: 21815
- 46 Sommer-Kamann C, Fries A, Mordhorst S, Andexer JN, Müller M. Angew Chem 2017; 129: 4091
- 47 Sommer-Kamann C, Breiltgens J, Zou Z. et al. ChemBioChem 2024; 25: e202400258
- 48 Xie Y, Ma J, Qin X, Li Q, Ju J. Microb Cell Fact 2017; 16: 177
- 49 Meyers AI, Lawson JP, Walker DG, Linderman RJ. J Org Chem 1986; 51: 5111
- 50 Helquist P, Bergdahl M, Hett R. et al. Pure Appl Chem 1994; 66: 2063
- 51 Schlessinger RH, Iwanowicz EJ, Springer JP. Tetrahedron Lett 1988; 29: 1489
- 52 Wood RD, Ganem B. Tetrahedron Lett 1983; 24: 4391
- 53 Liu L, Tanke RS, Miller MJ. J Org Chem 1986; 51: 5332
- 54 Tavares F, Lawson JP, Meyers AI. J Am Chem Soc 1996; 118: 3303
- 55 Meyers AI, Amos RA. J Am Chem Soc 1980; 102: 870
- 56 Butera J, Rini J, Helquist P. J Org Chem 1985; 50: 3676
- 57 Marcantoni E, Massaccesi M, Petrini M. et al. J Org Chem 2000; 65: 4553
- 58 Kuligowski C, Bezzenine-Lafollée S, Chaume G. et al. J Org Chem 2002; 67: 4565
- 59 Moreau X, Campagne J-M. J Org Chem 2003; 68: 5346
- 60 Chaume G, Kuligowski C, Bezzenine-Laffolée S, Ricard L, Pancrazi A, Ardisson J. Synthesis 2004; 2004: 3029
- 61 Ushimaru R, Abe I. TRECHEM 2023; 5: 526
- 62 Shi Y, Jiang Z, Li X. et al. Acta Pharm Sin B 2018; 8: 283
- 63 Wang Y, Wang J, Yu S. et al. ChemBioChem 2016; 17: 799
- 64 Morita I, Mori T, Mitsuhashi T. et al. Angew Chem Int Ed 2020; 59: 3988
- 65 Ge X, Long Y, Wang J. et al. Sci China Chem 2023; 66: 3232
- 66 He F, Mori T, Morita I. et al. Nat Chem Biol 2019; 15: 1206
- 67 Li X, Liu Y. Inorg Chem 2024; 63: 4086
- 68 Shi Y, Jiang Z, Hu X. et al. Angew Chem Int Ed 2021; 60: 15399
- 69 Zhang X, Xu X, You C. et al. Angew Chem Int Ed 2021; 60: 24418
- 70 Morita I, Mori T, Abe I. Chem Eur J 2021; 27: 2963
- 71 Sheehan JC, Ledis SL. J Am Chem Soc 1973; 95: 875
- 72 Okumura Y, Okamura K, Takei T. et al. J Antibiot 1979; 32: 575
- 73 Okumura Y, Takei T, Sakamoto M, Ishikura T, Fukagawa Y. J Antibiot 1979; 32: 1002
- 74 Okumura Y, Okamoto R, Ishikura T. Agric Biol Chem 1984; 48: 543
- 75 Kehoe LE, Snidwongse J, Courvalin P, Rafferty JB, Murray IA. J Biol Chem 2003; 278: 29963
- 76 Theuretzbacher U, Bush K, Harbarth S. et al. Nat Rev Microbiol 2020; 18: 286
- 77 Bryskier A. Clin Microbiol Infect 2000; 6: 661