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Synfacts 2025; 21(12): 1231
DOI: 10.1055/a-2720-7669
Polymer-Supported Synthesis

C−S Coupling of Thiols and Aryl Iodides Using a Copper Single-Atom Catalyst Supported on mpgCN

Autor*innen

Gazis TA, Palit S, Cipriano LA, Allasia N, Collins SM, Ramasse QM, Kwon IS, Sterrer M, Di Liberto G, Vilé G *. Politecnico di Milano, Italy
Copper Single-Atom Catalyst for Efficient C–S Coupling in Thioether Synthesis.

Angew. Chem. Int. Ed. 2025;
64: e202510632
DOI: 10.1002/anie.202510632
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Keywords

single atom catalysis - copper catalysis - C–S coupling - thioethers

Significance

Atomically dispersed Cu supported on a mesoporous carbon nitride (CuSA@mpgCN) was prepared according to equation 1. CuSA@mpgCN catalyzed the C−S coupling of thiols and aryl iodides in the presence of K2CO3 in 1,4-dioxane at 110 °C for 8 hours to afford the corresponding thioethers in up to 92 % yield (eq. 2).


Comment

In the C−S coupling of benzyl mercaptan and iodobenzene, the catalyst was recovered by centrifugation and reused four times without a significant loss of its catalytic activity. XRD, BET, XPS, and ICP-OES analyses of the recovered catalyst showed no obvious change in its morphology.




Publikationsverlauf

Artikel online veröffentlicht:
26. November 2025

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