Cu(acac)2-Catalyzed A3-(Aldehyde-amine-alkyne) Coupling Reaction for the Synthesis of a Wide Range of Propargylamines and Entry to Imidazo[1,2-a]pyridines

Upendra Pappula; Venkata Prasad Kalyana; Ujjal Kanti Roy

doi:10.1055/a-2695-8185

Synthesis, Table of Contents

Synthesis
DOI: 10.1055/a-2695-8185

Paper

Cu(acac)₂-Catalyzed A³-(Aldehyde-amine-alkyne) Coupling Reaction for the Synthesis of a Wide Range of Propargylamines and Entry to Imidazo[1,2-a]pyridines

Authors

Upendra Pappula

¹Advanced Synthesis and Catalysis Laboratory, Department of Chemistry, Kazi Nazrul University, Asansol, India (Ringgold ID: RIN525262)
Venkata Prasad Kalyana

¹Advanced Synthesis and Catalysis Laboratory, Department of Chemistry, Kazi Nazrul University, Asansol, India (Ringgold ID: RIN525262)
Ujjal Kanti Roy

¹Advanced Synthesis and Catalysis Laboratory, Department of Chemistry, Kazi Nazrul University, Asansol, India (Ringgold ID: RIN525262)

Abstract

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Abstract

Cu(acac)₂-catalyzed A³-coupling reactions involving an amine, an aldehyde, and a terminal alkyne were explored for the efficient synthesis of a broad range of propargylamines and imidazo[1,2-a]pyridines. This method demonstrates a wide substrate scope and delivers the desired products in good yields under mild reaction conditions. The protocol offers a straightforward and practical approach to accessing these valuable scaffolds, making it attractive for further synthetic applications.

Keywords

Copper catalyst - A³-Coupling - Propargylamines - Imidazo[1,2-a]pyridine

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References

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