Retinopathy of Prematurity and Neurodevelopmental and Quality-of-Life Outcomes at 10 Years of Age

Sudhir Sriram; Elizabeth T. Jensen; Michael E. Msall; Joe X. Yi; Vasyl Zhabotynski; Robert M. Joseph; Karl C.K. Kuban; Jean A. Frazier; Stephen R. Hooper; Hudson P. Santos Jr.; Semsa Gogcu; Christiane Dammann; Olaf Dammann; Jeffrey Shenberger; Rebecca C. Fry; Thomas Michael O'Shea; for the ELGAN-ECHO Study Investigators

doi:10.1055/a-2679-1788

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol
DOI: 10.1055/a-2679-1788

Original Article

Retinopathy of Prematurity and Neurodevelopmental and Quality-of-Life Outcomes at 10 Years of Age

Sudhir Sriram

¹Section of Neonatology, Department of Pediatrics, The University of Chicago, Chicago, Illinois

,

Elizabeth T. Jensen

²Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina

,

Michael E. Msall

³Kennedy Research Center on Intellectual and Neurodevelopmental Disabilities, University of Chicago Comer Children's Hospital Section of Developmental and Behavioral Pediatrics, Chicago, Illinois

,

Joe X. Yi

⁴Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina

,

Vasyl Zhabotynski

⁵Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, Chapel Hill, North Carolina

,

Robert M. Joseph

⁶Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts

,

Karl C.K. Kuban

⁷Division of Pediatric Neurology, Department of Pediatrics, Boston University Medical Center, Boston, Massachusetts

,

Jean A. Frazier

⁸Eunice Kennedy Shriver Center and Department of Psychiatry, University of Massachusetts Chan Medical Center, Worcester, Massachusetts

,

Stephen R. Hooper

⁹Department of Health Sciences, School of Medicine, University of North Carolina, Chapel Hill, North Carolina

,

Hudson P. Santos Jr.

¹⁰School of Nursing and Health Studies, University of Miami, Coral Gables, Florida

,

Semsa Gogcu

¹¹Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina

,

Christiane Dammann

¹²Department of Pediatrics, Tufts University Medical Center, Boston, Massachusetts

,

Olaf Dammann

¹³Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts

¹⁴Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway

,

Jeffrey Shenberger

¹⁵Department of Pediatrics, Connecticut Children's, Hartford, Connecticut

,

Rebecca C. Fry

⁵Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, Chapel Hill, North Carolina

,

Thomas Michael O'Shea

⁴Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina

,

for the ELGAN-ECHO Study Investigators

› Institutsangaben

Abstract

Objective

To evaluate, in a cohort of children born extremely preterm, the hypothesis that increasing severity of retinopathy of prematurity (ROP) is associated with less optimal vision, neurodevelopmental outcomes, and parent-reported quality of life.

Study Design

The Extremely Low Gestational Age Newborn study is a multicenter, longitudinal cohort study. Study participants were born before 28 completed weeks of gestation during the years 2002 to 2004 and were enrolled at birth at 14 U.S. hospitals. Based on retinal examinations by ophthalmologists, participants were classified during their initial hospitalization according to the severity of ROP. At 10 years of age, study psychologists evaluated participants' cognitive abilities, academic achievement, and behaviors indicative of autism spectrum disorder. Participants were classified with regard to gross motor function, anxiety, depression, and quality of life based on parents' responses on standardized questionnaires.

Results

After adjustment for confounders, increased severity of ROP was associated with increased severity of vision/eye problems, worse scores on math achievement tests, as well as higher prevalence of anxiety and lower quality of life as reported by the parent when the child was 10 years old. A history of blindness in one or both eyes was associated with these same outcomes, as well as worse scores on assessments of cognitive function, reading ability, and social responsiveness.

Conclusion

Among extremely preterm children, severe ROP and severe eye or vision problems are associated with adverse neurodevelopmental outcomes and lower quality of life.

Key Points

Severe retinopathy of prematurity in extremely low gestational age neonates (ELGANs) is likely to have adverse outcomes at 10 years of age.
Severe ROP in ELGANs is associated with parent-reported lower quality of life at 10 years.
Blindness in one or both eyes following ROP is associated with multiple adverse outcomes at 10 years.

Keywords

extremely low gestational age neonates - cognitive function - quality of life - retinopathy of prematurity

Volltext

Referenzen

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