Abstract
This review presents seminal advancements in enyne metathesis in nonusual media, including
green solvents, supercritical fluid, and microwave technology. Enyne metathesis has
been recognized as a powerful and innovative transformation in modern molecular chemistry,
enabling the efficient construction of complex cyclic and acyclic diene frameworks.
One can differentiate the enyne cross-metathesis, where an alkyne may react with an
alkene, from the ring-closing enyne metathesis, where the alkyne and alkene are part
of the same molecule. Both enyne transformations will be discussed in various solvents
such as water, ionic liquids, ethyl lactate, and dimethyl carbonate. The use of various
ruthenium-based complexes will be compared in each case. We will finally present tandem
processes implying enyne cross- or ring-closing metathesis and cyclization or reduction.
Keywords
Ruthenium - Enyne - Atom economy - Nonusual media - Green chemistry
