Recent Progress and Applications of Asymmetric Hydrogenation and Transfer Hydrogenation through Dynamic Kinetic Resolution

Marharyta Kosiuha; Anzhela Karapetyan; Olivier Charron; Christophe Meyer; Phannarath Phansavath; Virginie Ratovelomanana-Vidal

doi:10.1055/a-2646-6085

Synthesis, Table of Contents

Synthesis
DOI: 10.1055/a-2646-6085

Short Review

Recent Progress and Applications of Asymmetric Hydrogenation and Transfer Hydrogenation through Dynamic Kinetic Resolution

Marharyta Kosiuha

¹Chemistry, Chimie ParisTech – PSL, Paris, France

,

Anzhela Karapetyan

¹Chemistry, Chimie ParisTech – PSL, Paris, France

,

Olivier Charron

²Chemistry, ESPCI Paris, Paris, France

,

Christophe Meyer

²Chemistry, ESPCI Paris, Paris, France

,

Phannarath Phansavath

¹Chemistry, Chimie ParisTech – PSL, Paris, France

,

Virginie Ratovelomanana-Vidal

¹Chemistry, Chimie ParisTech – PSL, Paris, France

› Author Affiliations

Abstract

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Abstract

Given the growing demand for enantiomerically enriched compounds, the design of efficient, atom-economical, and sustainable synthetic strategies for the preparation of chiral alcohols and amines remains a critical objective in modern chemistry. This short, updated review highlights recent advances in homogeneous asymmetric catalysis employing transition-metal complexes in asymmetric hydrogenation (AH) and transfer hydrogenation (ATH) of ketones and imines under dynamic kinetic resolution (DKR) conditions to access these important building blocks. These methods enable the simultaneous formation of multiple stereogenic centers and have been significantly expanded through the development of novel catalytic systems and their application to previously unexplored classes of substrates.

Keywords

Asymmetric hydrogenation - Asymmetric transfer hydrogenation - Dynamic kinetic resolution - Chiral alcohols - Chiral amines - Stereoselectivity - Ketones - Imines

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References

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