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Synfacts 2025; 21(08): 849
DOI: 10.1055/a-2639-4214
DOI: 10.1055/a-2639-4214
Peptide Chemistry
Iron-Catalyzed Glycal 1,2-cis-Aminoglycosylation for the Synthesis of Biologically Active Tn Antigens
Yin L,
Zhang D,
Jiang Z,
Xu H *.
Brandeis University, Waltham, USA
Stereoselective Multigram-Scale Tn Antigen Synthesis via the Iron-Catalyzed Glycal 1,2-cis-Aminoglycosylation.
Org. Lett. 2025;
27: 5515-5520
DOI: 10.1021/acs.orglett.5c01560
Stereoselective Multigram-Scale Tn Antigen Synthesis via the Iron-Catalyzed Glycal 1,2-cis-Aminoglycosylation.
Org. Lett. 2025;
27: 5515-5520
DOI: 10.1021/acs.orglett.5c01560
Significance
Aminoglycosylation is an important strategy for synthesizing biologically active molecules and complex natural products. In this study, the authors developed an iron-catalyzed glycal 1,2-cis-aminoglycosylation for the synthesis of optically active Tn antigens.
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Comment
A series of optically active Tn antigens is synthesized by iron-catalyzed glycal 1,2-cis-aminoglycosylation of galactosyl donors with amino acid acceptors. The reactions proceed smoothly to afford the desired products in good yields and with excellent optical purities.
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Publication History
Article published online:
23 July 2025
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