DOI: 10.1055/s-00000131

Synfacts

Issue 08 · Volume 21 · August 2025 DOI: 10.1055/s-015-62003

Synthesis of Natural Products

z759
All PDFs of this category
759
Total Synthesis of (±)-Ambiguine P
760
Total Synthesis of (–)-Illisimonin A
761
Total Synthesis of (+)-Rubriflordilactone A
762
Total Synthesis of (–)-Isodaphlongamine H
763
Total Synthesis of (–)-Vallesamidine
764
Total Synthesis of (–)-Psiguadial A
765
Total Synthesis of (±)-Epoxysorbicillinol

Synthesis of Heterocycles

z767
All PDFs of this category
767
Enantioselective Synthesis of Spirocyclic Pyrrolidine Derivatives
768
Selective C–H Allylation of Tertiary Anilines
769
In Situ Generation of a Hypervalent Iodine Catalyst for the Fluorination of Ketones
770
A Facile Method for Preparing 5-Amino-1H-Pyrazole-4-Carbonitriles
771
Enantioselective Intermolecular Hydroarylation of (Hetero)aryl Halides
772
Accessing Macrocycles via a Strain-Release and Palladium-Mediated Templating Strategy
773
Regioselective meta-Nitration of Azines
774
Scalable Nickel-Mediated Formation of (Hetero)aryl Nitriles
775
Enantioselective Synthesis of 2-Aza-bicyclo[2.1.1]hexanes

Synthesis of Materials and Unnatural Products

z777
All PDFs of this category
777
Thermally Degradable Photopolymers for 3D Printing
778
A Low-Cost, Optical-Glass Photopolymer Containing a Disulfide Bond
779
Spin-Tuned Divergent Topochemical Polymerizations
780
A Chiral Double [8]Helicene
781
An Azulene-Composed Non-Alternant Isomer of Perylene
782
A [6+6] Cycloaddition Enabled by Anthrylethynylaniline
783
Aromatization-Driven Production of Aminoxoboranes
784
Rhodium-Catalyzed Mechanochemical Hydrogenation of Polycyclic Aromatic Hydrocarbons
785
N-Heterobicyclic Olefins: A New Type of Synthon and Ligand
786
Photo-degradation of Polyoxymethylenes into Imidazolidines

Metals in Synthesis

z787
All PDFs of this category
787
Cobalt-Catalyzed Enantioselective Hydrogenation of 2-Hydroxy Ketones to Access 1,2-Diols
788
A Light Way to Oxidize Benzylic C(sp3)–H Bonds Using Copper
789
A Decarboxylative Acylation Strategy for the Enantioconvergent Synthesis of α-Oxygenated Ketones
790
Radical Sorting Enables Decarboxylative Monofluoromethylation under Nickel Catalysis
791
Synthesis of Polysubstituted Cyclobutenes by Nickel-Catalyzed Cross-Electrophile Coupling
792
Double C–H Functionalization Enables Access to ortho-Arylated Benzoic Acids
793
Copper-Catalyzed Asymmetric Allylic and Propargylic C–H Amidation under Light Irradiation
794
Mn-Catalyzed XAT of Diborylatediodomethane with Unactivated Olefins and Synthesis of Cyclopropanes
795
Dual Nickel/Photoredox-Catalyzed Decarboxylative Cross-Coupling of Carboxylic Acids with Aldehydes
796
Synthesis of Complex Tetrahydrofurans via a Charge-Relocation Strategy
797
Cobalt-Catalyzed Enantioconvergent Negishi Cross-Coupling of α-Bromo-α-Fluoro Ketones
798
Photoredox-Catalyzed Aminochlorination of Unactivated Alkenes
799
Palladium-Catalyzed Asymmetric Cross-Coupling of Cyclobutanecarbaldehyde-Derived N-Tosylhydrazones
800
Nickel-Catalyzed Desulfonylative Suzuki−Miyaura Cross-Coupling of Unactivated Aryl Sulfones
801
Nickel-Catalyzed Asymmetric Synthesis of α-Arylated Ketones from two Distinct Alkenes
802
Copper-Catalyzed Asymmetric Borylalkylation of Styrenes
803
Titanium-Catalyzed Reductive Ugi Reaction with Carboxylic Acids
804
Palladium-Catalyzed Synthesis of Benzo-Fused Cycloheptanones
805
Cerium-Catalyzed Enantioselective 6π Electrocyclization of Triaryldivinyl Ketones
806
Epoxide Radical Anions in Asymmetric Copper Catalysis
807
Enantioselective C(sp2)–H Cyanation of Allenes under Copper Catalysis
808
Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Alkyl Chlorides
809
Hydroalkoxylation of Styrenes with Acetal-Based Peroxides under Copper Hydride Catalysis
810
Dynamic Kinetic Resolution of Axially Chiral Compounds – Catalyst Selective for Both Point and Axial Chirality
811
Access to Axially Chiral Alkylidene Azacycloalkanes by Rhodium(I)-Catalyzed Carbene Coupling
812
Photochemical Reductive Palladium Homocoupling of Diene Tethered Aryl Iodides

Polymer-Supported Synthesis

z813
All PDFs of this category
813
Oxidative Nitrogenation of Alkenes through C=C Bond Cleavage Using a Zeolite-Supported Copper Catalyst
814
Chemo- and Regioselective Deuteration of (Hetero)arenes Using SiO2-Supported Iridium Nanoparticles
815
Photoinduced Multicomponent Reactions Forming Imidazolidines Using Sulfonic Acid Modified g-C3N4
816
Si–F Activation for Si–O Bond-Forming Reactions Using a Cross-Linked Polymer-Supported Ruthenium Catalyst
817
4-Quinazolinones from Allylic Alcohols and o-Aminobenzamides Using a COF-Supported Ru Complex
818
An Amphiphilic Polymer-Supported Palladium Complex for the Suzuki–Miyaura Coupling in Water
819
Selective Synthesis of α,β-Unsaturated Aldehydes Using H2O2 Generated by an Electrochemical Reaction
820
Acceptorless Dehydrogenation of Alcohols Using Single-Atom Pt and Ir on NiO Nanosheet
821
Photocatalytic Aerobic Oxidation of Alkylbenzenes, Silanes, Thioethers, and CDC Reaction Using 3D-COF
822
A Coordination Polymer of a Pd6 Cluster: A Water-Compatible Hydrogenation Catalyst
823
Iodination of Electron-Deficient Arenes under Electrochemical Conditions

Organo- and Biocatalysis

z825
All PDFs of this category
825
Light-Driven Enantioselective Acylation of Benzylic C–H Bonds Using Thiamine-Dependent Enzymes
826
Embedding a Triplet Sensitizer Into the Catalytic Pocket of an Enzyme to Enable Photocatalytic C–H Insertion
827
Organocatalytic Cyclopropanation of Olefins
828
Biocatalytic Enantiodivergent Synthesis of Cyclohexylidene-Based Axially Chiral Amines
829
Stereoretentive SN1 Reactions of Homoallylic Tertiary Alcohols via Cyclopropyl Carbinyl Carbocations
830
Dipolar Cycloaddition of Photoexcited Nitroarenes
831
Organocatalytic Asymmetric Synthesis of Azabicyclo[2.1.1]hexanes
832
1,2-Acyl Group Migration in Dihydrobenzofurans Enabled by Photochemical Skeletal Editing
833
Enantioselective Construction of Polycycles via Type II Intramolecular [5+2] Cycloadditions

Innovative Drug Discovery and Development

z835
All PDFs of this category
835
Discovery and Development of INCB126503: A Potent and Selective FGFR2/3 Inhibitor
836
A Concise Formal Synthesis of (−)-Paroxetine
837
Leveraging Small-Molecule Heat Generation as a Noninvasive Apoptotic Tool
838
Reagent-Controlled Divergent Carbon Deletion of Quinolines via Carbon-Atom Scavengers
839
Development of Dual DAT/σR Inhibitor CM699 as a Potential Therapeutic for Stimulant Use Disorder
840
Tuning Chiral Catalysts with Achiral Additives
841
18F-Labeling of α,α-Difluoromethylalkanes in High Molar Activity
842
A 5-exo-trig Cyclization Strategy Crafts Modular Cyanine Probes for High-Contrast Biomarker Detection
843
Gram-Scale Synthesis of an Antibody Fucosylation Inhibitor
844
A Structurally Simplified Derivative Retains the Bioactivity of Colchicine
845
Hydrogen Sulfide Meets Phototherapy: A Synergistic Approach to Chronic Wound Treatment
846
Ketone Homologation with Titanium and DMF
847
A Novel and Safer Approach to Furazan Carboxylic Esters from Enamines

Peptide Chemistry

z849
All PDFs of this category
849
Iron-Catalyzed Glycal 1,2-cis-Aminoglycosylation for the Synthesis of Biologically Active Tn Antigens
850
Thiol-Michael Addition of Thiolated Lipids at Dehydroalanine-Residue-Containing Peptides
851
Palladium-Catalyzed Coupling to Form α,α-Disubstituted Amino Acids
852
Racemization-Free Peptide Coupling Using a Green Coupling Agent
853
Enantioselective Synthesis of Unnatural Polar Amino Acids
854
Total Synthesis of the Cyclic Heptapeptide Stylissamide B
855
Synthesis of Quaternary Glutamates via Direct Enantioselective Allylic Alkylation of α‐Amino Esters
856
Synthesis of Amino Amides via Asymmetric Vicinal and Remote Hydroamination of Olefins
857
Photocatalyzed Desulfurization Editing of Methionine in Peptides
858
Incorporation of Thioate Groups into Peptides Using a CS2-Mediated Solid-Phase Strategy
859
Late-Stage Functionalization of Peptides with Amines Using a Solid-Phase Approach
860
Synthesis of Cyclopropane α-Amino Acids

Flow Chemistry

z861
All PDFs of this category
861
Expedient Access to Functionalized Cyclopropenes via Continuous Flow Conditions
862
An Atom-Economic Approach to Cyclic Sulfonamides via Photochemical [2+2] Cycloaddition
863
Continuous-Flow Preparation of Nitrofuran Active Pharmaceutical Ingredients

Correction

865
Correction: A Practical Strategy for the Chemoselective Synthesis of O-Alkylated Serine and Threonine Derivatives
866
Correction: Rationally Designed Phosphine Ligand to Enable Challenging Palladium-Mediated Aminations