I₂-DMSO-Mediated Three-Component Cyclization of 2-Aminobenzimidazole to Access 2,3-Substituted Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives

Abstract

An I₂-DMSO-mediated, one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine-2,3-diylbis(phenylmethyl ketone) derivatives have been developed using 2-aminobenzimidazole, acetophenone, and enaminone as starting materials. The structures of the compounds were characterized by single-crystal X-ray diffraction.

Keywords

Benzo[4,5]imidazo[1,2-a]pyrimidine-2,3-diylbis(phenylmethyl ketone) - Enaminone - I₂-DMSO-mediated - Three-component reaction - Metal-free

Publication History

Received: 24 February 2025

Accepted after revision: 09 June 2025

Article published online:
24 July 2025

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