“On-water” Photochemical Thiol-Ene Reaction of N-Enoxybenzotriazoles

Abstract

We report herein a photochemical thiol-ene coupling using N-enoxybenzotriazoles, significantly accelerated under “on-water” conditions. This approach achieves efficient coupling within just five minutes via a remarkably rapid radical chain reaction, attributed to enhanced EDA formation and accelerated radical addition through a hydrophobic effect. The robustness of this method under various perturbation conditions underscores its potential for broad applications.

Keywords

On water - Photocatalysis - Thiol-ene reaction - Radical chain - Catalyst-free

Publication History

Received: 26 April 2025

Accepted after revision: 06 June 2025

Accepted Manuscript online:
06 June 2025

Article published online:
01 August 2025

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