Lewis Acid-Catalyzed Cyanomethylation of α,β-Unsaturated Keto Esters and Activated Ketones Using Vinyl Azide as an Acetonitrile Equivalent

Abstract

Lewis acid-catalyzed cyanomethylation reactions of α,β-unsaturated ketoesters and ketoamides with α-isopropanol vinyl azide were reported. The corresponding cyanoalkylated products were obtained in 40–97% and 45–96% yields, respectively, through 1,4- and 1,2-addition pathways.

Keywords

Cyanomethylation reaction - Ketoester - Ketoamide - Vinyl azide

Publication History

Received: 08 May 2025

Accepted after revision: 04 June 2025

Accepted Manuscript online:
04 June 2025

Article published online:
24 July 2025

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