Deuterated Oxazoloisoindolinones via Photocatalytic Deoxygenative Cyclization of Amino Acid Derivatives

Abstract

A stereoselective synthesis of deuterated oxazoloisoindolinones using D₂O was achieved through photocatalytic deoxygenation of readily available N-phthalimide amino acids, followed by an intramolecular 5-endo-trig cyclization. This protocol provides an efficient access to a broad array of deuterium-labeled N,O-heterobicycles with excellent deuterium incorporation.

Keywords

Amino acid - Photocatalytic deoxygenation - Cyclization - Deuterium incorporation - Oxazoloisoindolinone

Publication History

Received: 31 March 2025

Accepted after revision: 19 May 2025

Accepted Manuscript online:
20 May 2025

Article published online:
13 August 2025

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