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DOI: 10.1055/a-2608-2142
Electrochemical Synthesis of Ketones via Metal-Free Decarboxylative Coupling of Vinyl Azides and NHPI Esters
S.S. acknowledge support from the Anusandhan National Research Foundation (ANRF, formerly SERB), India (CRG/2023/00713) and Rashtriya Uchchatar Shiksha Abhiyan (RUSA 2.0, MLSU-Udaipur). S.S.B. thanks the Banaras Hindu University for providing financial support as seed grant under Institute of Eminence Scheme. B.J. is thankful to the University Grants Commission (UGC) for the JRF fellowship.
Abstract
We introduce a metal-free method for C–C bond formation by coupling NHPI esters with vinyl azides through electrochemical synthesis. By converting carboxylic acids into radical-initiating NHPI esters, our approach achieves efficient C(sp³)–C(sp3) bond formation without needing metal catalysts. This method is highly adaptable, enabling the coupling of various NHPI esters with a broad range of vinyl azides, including those with halide or heteroatom substitutions.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2608-2142.
- Supporting Information
Publication History
Received: 23 March 2025
Accepted after revision: 14 May 2025
Accepted Manuscript online:
14 May 2025
Article published online:
18 June 2025
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