Abstract
In this Account, we describe our recent research progress in the development of the
functionalization of unsaturated substrates catalyzed by low-valent nickel. In particular,
we discuss nickel-catalyzed azide–alkyne cycloaddition (NiAAC), [2 + 2 + 2] cycloaddition
of diynes and nitriles, hydrosilylation of alkynes, and dicarbofunctionalization of
1,3-enynes. Moreover, we highlight our mechanistic studies aimed at elucidating catalytically
active nickel intermediates, thereby contributing to the understanding and expansion
of nickel-catalyzed synthetic methodologies.
1 Introduction
2 Nickel(0)-Catalyzed Cycloaddition Reactions
3 Nickel(I)-Catalyzed Hydrosilylation and Dicarbofunctionalization Reactions
4 Conclusion and Outlook
Key words
unsaturated systems - nickel - cycloaddition - hydrosilylation - dicarbofunctionalization
- regioselectivity - reaction mechanisms
