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DOI: 10.1055/a-2577-4281
Nickel/Photoredox-Catalyzed Three-Component Dialkylation of Alkenes for the Synthesis of β-Amino Acid Derivatives
We are grateful to the National Natural Science Foundation of China (22201087) for financial support.
Abstract
β-Amino acid-containing structures show important biological activity and are found widely in many pharmacologically active compounds; therefore, the development of efficient methods for the synthesis of β-amino acid derivatives has evoked considerable interest in the past decades. Herein, we report a nickel/photoredox-catalyzed synthesis of β-amino acid derivatives from readily available alkyl redox-active esters, alkenes, and α-silylamines. This reaction is characterized by a broad substrate scope, mild conditions, and excellent selectivity. Mechanistic studies suggest that the reaction proceeds through a radical pathway.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2577-4281.
- Supporting Information
Publication History
Received: 27 February 2025
Accepted after revision: 08 April 2025
Accepted Manuscript online:
08 April 2025
Article published online:
22 May 2025
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