Synlett
DOI: 10.1055/a-2577-2065
letter
Emerging Trends in Organic Chemistry: A Focus on India

Efficient Green Synthesis of Imidazo[2,1-b]thiazol-5-yl-2,4-dihydropyrano[2,3-c]pyrazole Derivatives Using HPA-Montmorillonite-KSF

Pragati Kushwaha
a   Department of Chemistry, University of Lucknow, Lucknow-226007, Uttar Pradesh, India
,
Ayush Bhardwaj
a   Department of Chemistry, University of Lucknow, Lucknow-226007, Uttar Pradesh, India
,
Rashi Rashi
a   Department of Chemistry, University of Lucknow, Lucknow-226007, Uttar Pradesh, India
,
Danish Khan
b   Department of Chemistry, Indian Institute of Technology, Roorkee-247667, Uttarakhand, India
,
Maneesh Kumar Gupta
c   Department of Chemistry, H.R. College, Amnour, Jai Prakash University, Chapra, Bihar, India
› Institutsangaben
P.K. express her gratitude to Council of Science and Technology, U.P. (No. CST/D-795) and University Grants Commission (UGC), New Delhi (F.30-507/2020(BSR) for financial assistance. M.K.G. is thankful to Science and Engineering Research Board (SERB) for TARE (TAR/2023/000454) research grant, New Delhi.


Abstract

Herein, we developed a simple, efficient, cost-effective, recyclable, and green approach for synthesizing imidazo[2,1-b]thiazol-5-yl-2,4-dihydropyrano[2,3-c]pyrazole derivatives. The reaction protocol involves ‘HPA-montmorillonite-KSF’ as a reusable and heterogeneous catalyst and proceeds via multicomponent reaction (MCR). Various substituted imidazo[2,1-b]thiazol-5-yl-2,4-dihydropyrano[2,3-c]pyrazole derivatives were prepared in good to excellent isolated yields. This methodology is compatible with the gram-scale synthesis and provides an efficient and much improved modification of the original MCR, considering the yield and mild reaction conditions.

Supporting Information



Publikationsverlauf

Eingereicht: 17. Februar 2025

Angenommen nach Revision: 07. April 2025

Accepted Manuscript online:
07. April 2025

Artikel online veröffentlicht:
14. Mai 2025

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