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Thromb Haemost
DOI: 10.1055/a-2572-1170
Coagulation and Fibrinolysis

Implications of Soluble C-type Lectin-Like Receptor 2 Levels in Patients with Coronavirus Disease 2019-Associated with Thrombosis

Hideo Wada
1   Department of General Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Katsuya Shiraki
1   Department of General Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Yuhuko Ichikawa
2   Department of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Nobuo Ito
3   Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Hidekazu Inoue
4   Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Isao Moritani
4   Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Jun Masuda
5   Department of Cardiovascular Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Akitaka Yamamoto
6   Department of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Masaki Tomida
6   Department of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Masamichi Yoshida
7   Department of Respiratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan
,
Masahide Kawamura
8   IVD Division, PHC Corporation, Tokyo, Japan
,
Motomu Shimaoka
9   Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Japan
,
Toshiaki Iba
10   Department of Emergency and Disaster Medicine, Juntendo University, Graduate School of Medicine, Tokyo, Japan
,
Hideto Shimpo
11   Mie Prefectural General Medical Center, Yokkaichi, Japan
› Author Affiliations Funding This research was funded by a Grant-in-Aid from the Ministry of Health, Labor and Welfare of Japan (21FC1008).
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Abstract

Background

Coronavirus disease 2019 (COVID-19) is often associated with thrombosis. Elevated levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a biomarker for platelet activation, have been reported in COVID-19. Therefore, we examined the behavior of sCLEC-2 levels and their relationship with thrombosis.

Methods

The clinical course of inflammatory and thrombotic biomarkers was assessed in 271 patients with COVID-19.

Results

Inflammatory biomarkers such as C-reactive protein, procalcitonin, and presepsin levels were significantly increased in patients with COVID-19, and these behaviors differed among the clinical course or stages. The plasma D-dimer levels increased slightly and gradually. Platelet counts were within the normal range, and plasma sCLEC-2 levels were markedly increased in most patients with COVID-19. There were 17 patients with thrombosis in this study. Although there was no significant difference in various biomarkers between COVID-19 patients with and without thrombosis, the super formula of sCLEC-2xD-dimer/platelet count in patients with thrombosis was significantly higher than in those without thrombosis. Furthermore, this super formula was significantly higher in COVID-19 patients with severe or critical illness than in those with mild or moderate illness.

Conclusion

Elevation of the super formula of sCLEC-2xD-dimer/platelet count was associated with the thrombosis in patients with COVID-19 suggesting the thrombosis in COVID-19 may be caused by the development of microthrombosis.

Keywords

COVID-19 - sCLEC-2 - severity - clinical course - microthrombosis


Publication History

Received: 10 February 2025

Accepted: 01 April 2025

Accepted Manuscript online:
02 April 2025

Article published online:
29 April 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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