Abstract
Trimethylsilyl triflate has emerged as a powerful and versatile Lewis acid catalyst
in organic synthesis, offering high efficiency under mild reaction conditions. It
is known for its strong electrophilic activation and is widely used for C–C bond formation,
heterocyclic synthesis, and protecting-group transformations. Herein, a straightforward
synthesis of various biologically and synthetically important compounds, including
2H-chromenes, coumarins, furans, pyrans, and chalcones, has been achieved through carbonyl–alkyne
metathesis reactions with trimethylsilyl triflate as a Lewis acid catalyst.
Key words
carbonyl–alkyne metathesis - chromenes - coumarins - chalcones - trimethylsilyl triflate
- organocatalysis
