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Synlett
DOI: 10.1055/a-2535-0823
DOI: 10.1055/a-2535-0823
letter
First-Row Transition-Metal Catalysis for Organic Synthesis.
Cobalt-Catalyzed Reductive Heck Cyclization Using Water as Hydrogen Donor to Access Oxindoles
The project is supported by the National Natural Science Foundation of China (22171177), the Guangdong-Hong Kong Joint Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province (2023B1212120011), the Characteristic Innovation Project of Guangdong Colleges and Universities (2024KTSCX108), the 2022 Scientific Research Start-up Funds of Hanshan Normal University (QD202208), and the Guangdong Basic and Applied Basic Research Foundation (2023A1515110791).
Abstract
An efficient cobalt-catalyzed intramolecular reductive Heck reaction using water as hydrogen donor for the synthesis of valuable 3,3-disubstituted oxindoles from 2-halo-N-arylacrylamides is described. The approach features operational simplicity and high functional group tolerance. Importantly, when the reaction was performed in D2O, the deuterated oxindoles could be rapidly accessed in a facile and low-cost manner.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2535-0823.
- Supporting Information
Publication History
Received: 12 January 2025
Accepted after revision: 07 February 2025
Accepted Manuscript online:
07 February 2025
Article published online:
21 March 2025
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