Synlett 2025; 36(10): 1418-1422
DOI: 10.1055/a-2522-6819
letter

Thermal-Mediated Synthesis of Hydantoin Derivatives from Amino Acids via Carbodiimide Reagents

Fatma Albayrak Halac
,
Selin Meral
,
Mehmet Mart
,
Ramazan Altundas
,

This study was supported by Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TUBITAK) under grant number 123Z894. The authors thank TUBITAK for the support.


Abstract

We introduce an innovative methodology for synthesizing hydantoins from amino acids using readily available carbodiimides, emphasizing the crucial role of temperature in the reaction process. This approach presents significant advantages over conventional methods involving isocyanates, facilitating easier handling and minimizing associated risks. Our strategy not only allows for the efficient production of a diverse array of hydantoin derivatives but also adheres to environmentally sustainable practices. The optimized reaction conditions enhance efficiency, marking a significant advancement in the field of organic synthesis. This method presents significant advantages for industrial applications, as it is a heat-mediated process that does not require the use of any bases or catalysts. By eliminating the need for additional reagents, this approach simplifies the reaction conditions, reduces potential side reactions, and minimizes the overall environmental impact. Additionally, the absence of catalysts streamlines the purification process, making it more cost-effective and efficient for large-scale production.

Supporting Information



Publication History

Received: 04 January 2025

Accepted after revision: 22 January 2025

Accepted Manuscript online:
22 January 2025

Article published online:
12 March 2025

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