Abstract
Objective This study aimed to determine the prevalence of septo-optic dysplasia (SOD) in patients
with prenatally identified absent cavum septi pellucidi (CSP), agenesis of the corpus
callosum (ACC), or dysgenesis of the corpus callosum (DCC).
Study Design This retrospective chart review investigated neonates prenatally diagnosed with an
absent CSP, ACC, or DCC who were admitted to a single quaternary academic medical
center in the Pacific Northwest between 2016 and 2023. This prenatal diagnosis prompted
a routine and protocolized postnatal workup for SOD including laboratory evaluation,
imaging, and specialty consultation. Sociodemographic and clinical data were collected
for eligible neonates and their birthing persons. The prevalence of SOD in patients
with midline callososeptal anomalies was calculated.
Results Of the 86 patients prenatally diagnosed with absent CSP, ACC, and/or DCC, 36.0% (n = 31) were diagnosed postnatally with SOD. Of those diagnosed with SOD, 71.0% (n = 22) had isolated optic nerve hypoplasia, 9.7% (n = 3) had pituitary hormone abnormalities, and 19.4% (n = 6) had both. Seven patients required maintenance hydrocortisone, one required thyroid
hormone replacement, and one required thyroid and growth hormones. Of the 26 patients
with SOD who underwent genetic testing, 9 (34.6%) had one or more genetic differences
detected.
Conclusion SOD was diagnosed in 36.0% of cases of prenatally diagnosed midline callososeptal
anomalies. For patients with prenatally diagnosed midline callososeptal anomalies,
a standardized, postnatal SOD evaluation allows timely diagnosis and prompts early
intervention and hormone replacement, thus avoiding the consequences of a delayed
diagnosis.
Key Points
-
Thirty-six percent of patients with midline callososeptal anomalies were diagnosed
with SOD.
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Most patients (71.0%) diagnosed with SOD had optic nerve hypoplasia without pituitary
abnormalities.
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Although most patients received genetic testing, no findings were linked to SOD.
Keywords
septo-optic dysplasia - cavum septi pellucidi - corpus callosum - midline brain defects
- callososeptal anomalies
